Steven M Paul Selected Research

xanomeline

11/2022	Antipsychotic Efficacy of KarXT (Xanomeline-Trospium): Post Hoc Analysis of Positive and Negative Syndrome Scale Categorical Response Rates, Time Course of Response, and Symptom Domains of Response in a Phase 2 Study.
1/2022	Muscarinic Acetylcholine Receptor Agonists as Novel Treatments for Schizophrenia.
1/2022	Biased Profile of Xanomeline at the Recombinant Human M4 Muscarinic Acetylcholine Receptor.
1/2021	Muscarinic Cholinergic Receptor Agonist and Peripheral Antagonist for Schizophrenia.

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Steven M Paul Research Topics

Disease

54	Pain (Aches) 06/2022 - 02/2002
52	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 03/2002
36	Fatigue 04/2022 - 02/2008
32	Neoplasms (Cancer) 01/2023 - 10/2002
29	Breast Neoplasms (Breast Cancer) 05/2022 - 05/2010
21	Amyloid Plaque 06/2015 - 03/2002
16	Lung Neoplasms (Lung Cancer) 06/2022 - 08/2015
13	Syndrome (Syndromes) 07/2022 - 11/2009
12	Postoperative Pain 01/2019 - 03/2003
11	Peripheral Nervous System Diseases (PNS Diseases) 01/2022 - 01/2018
9	Prostatic Neoplasms (Prostate Cancer) 01/2017 - 02/2008
8	Nausea 05/2022 - 06/2005
8	Cognitive Dysfunction 04/2022 - 03/2002
7	Cancer Pain 06/2022 - 02/2002
7	Gastrointestinal Neoplasms (Gastrointestinal Cancer) 03/2022 - 02/2017
6	Constipation 05/2022 - 04/2002
6	Mastodynia 11/2017 - 05/2012
5	Schizophrenia (Dementia Praecox) 11/2022 - 01/2021
5	Neoplasm Metastasis (Metastasis) 06/2014 - 02/2002
4	Vomiting 05/2022 - 06/2005
4	Head and Neck Neoplasms (Head and Neck Cancer) 11/2015 - 01/2003
3	Neuroinflammatory Diseases 12/2021 - 01/2017
3	Mood Disorders (Mood Disorder) 05/2020 - 09/2002
3	Major Depressive Disorder (Major Depressive Disorders) 11/2019 - 08/2014
3	Hearing Loss (Hearing Impairment) 02/2018 - 01/2018
3	Tinnitus 02/2018 - 01/2018
3	Amyloidosis 01/2016 - 10/2004
3	Brain Neoplasms (Brain Tumor) 03/2015 - 01/2012
3	Brain Diseases (Brain Disorder) 05/2011 - 12/2003
3	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 03/2005 - 08/2003
3	Inflammation (Inflammations) 12/2003 - 09/2002
2	Dyspnea (Shortness of Breath) 10/2021 - 04/2008
2	Postpartum Depression (Post-Natal Depression) 05/2020 - 11/2019
2	Anxiety Disorders (Anxiety Disorder) 11/2019 - 01/2013
2	Dizziness (Lightheadedness) 01/2019 - 06/2005
2	Lymphedema (Milroy Disease) 03/2017 - 03/2014
2	Tauopathies 01/2017 - 12/2016
2	Neurobehavioral Manifestations 01/2017 - 11/2009
2	Disease Progression 01/2017 - 09/2002
2	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2016 - 07/2002
2	Chronic Obstructive Pulmonary Disease (COPD) 01/2016 - 04/2008

Drug/Important Bio-Agent (IBA)

24	Amyloid beta-PeptidesIBA 03/2010 - 03/2002
23	Amyloid (Amyloid Fibrils)IBA 01/2017 - 03/2002
22	Apolipoproteins E (ApoE)IBA 06/2020 - 04/2002
21	Analgesics (Analgesic Drugs)IBA 01/2020 - 02/2002
19	CytokinesIBA 01/2018 - 09/2002
16	ApolipoproteinsIBA 01/2019 - 04/2002
16	Proteins (Proteins, Gene)FDA Link 12/2009 - 09/2002
10	Peptides (Polypeptides)IBA 06/2015 - 03/2002
9	Opioid Analgesics (Opioids)IBA 01/2017 - 02/2002
6	Apolipoprotein E4IBA 01/2018 - 12/2002
5	Protein Isoforms (Isoforms)IBA 06/2020 - 04/2002
5	Interleukin-6 (Interleukin 6)IBA 11/2017 - 09/2002
4	xanomelineIBA 11/2022 - 01/2021
4	Pharmaceutical PreparationsIBA 01/2021 - 07/2009
4	Paclitaxel (Taxol)FDA LinkGeneric 10/2019 - 01/2018
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 11/2017 - 07/2009
4	Potassium Channels (Potassium Channel)IBA 03/2017 - 03/2014
4	InterleukinsIBA 01/2017 - 05/2012
4	AntibodiesIBA 12/2016 - 12/2002
4	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2016 - 01/2008
4	Acetaminophen (Paracetamol)FDA LinkGeneric 03/2012 - 07/2004
4	CholesterolIBA 01/2011 - 09/2003
4	Nalbuphine (Nubain)FDA LinkGeneric 04/2008 - 03/2003
3	PlatinumIBA 01/2022 - 01/2018
3	taxaneIBA 01/2022 - 01/2018
3	AntiemeticsIBA 01/2021 - 01/2020
3	LipidsIBA 06/2020 - 09/2003
3	Apolipoprotein E2IBA 01/2018 - 01/2005
3	LigandsIBA 11/2017 - 02/2004
3	Biological ProductsIBA 01/2017 - 12/2003
3	Monoclonal AntibodiesIBA 12/2016 - 05/2002
3	Naloxone (Narcan)FDA LinkGeneric 04/2008 - 03/2003
3	Narcotic Antagonists (Opioid Antagonists)IBA 04/2008 - 03/2003
2	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 01/2022 - 01/2022
2	Antipsychotic Agents (Antipsychotics)IBA 01/2022 - 03/2006
2	Cholinergic Agents (Cholinergics)IBA 01/2021 - 03/2006
2	Pregnanolone (Allopregnanolone)IBA 05/2020 - 11/2019
2	gamma-Aminobutyric Acid (GABA)IBA 05/2020 - 01/2019
2	brexanoloneIBA 05/2020 - 11/2019
2	NeurosteroidsIBA 11/2019 - 01/2013
2	ChemokinesIBA 11/2017 - 01/2017
2	Interleukin-13IBA 01/2017 - 05/2012
2	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 01/2017 - 02/2014
2	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2017 - 12/2009
2	Interleukin-10 (Interleukin 10)IBA 11/2016 - 02/2014
2	C-Reactive ProteinIBA 01/2016 - 09/2003
2	PotassiumIBA 03/2015 - 03/2014
2	Interleukin-4 (Interleukin 4)IBA 03/2015 - 06/2012
2	solanezumabIBA 07/2012 - 03/2010
2	Biomarkers (Surrogate Marker)IBA 07/2012 - 09/2003
2	Hydrocodone (Dihydrocodeinone)FDA LinkGeneric 03/2012 - 02/2010

Therapy/Procedure

69	Drug Therapy (Chemotherapy) 01/2023 - 07/2010
27	Radiotherapy 01/2017 - 01/2003
11	Pain Management 04/2022 - 04/2002
11	Therapeutics 12/2021 - 09/2002
5	Tonsillectomy 03/2012 - 07/2004
3	Lymph Node Excision (Lymph Node Dissection) 10/2020 - 02/2013
3	Analgesia 04/2008 - 03/2003
2	Knee Replacement Arthroplasty (Total Knee Replacement) 01/2017 - 01/2016